Parkinson’s Disease and Psychotic Disorder – The Dopamine Ying-Yang

Parkinson’s Disease and Psychotic Disorder – The Dopamine Ying-Yang

KL is a 79 year old male with a history of Parkinson’s disease.  About 2 weeks ago, he had been having worsening symptoms of rigidity and his wife is concerned with this newer development.  At that time, his Sinemet dosing was increased from 25/100 TID to 50/200 TID....
Acetylcholinesterace Inhibitors – Clinical Pearls, Common Mistakes

Acetylcholinesterace Inhibitors – Clinical Pearls, Common Mistakes

The acetylcholinesterace inhibitors are used almost exclusively for dementia.  Here’s a few clinical pearls and common mistakes that I’ve seen with them. GI symptoms – Diarrhea, nausea, and vomiting are common adverse effects.  Be on the lookout for...
5 Clinical Concerns you have to know with NSAIDs in the Elderly

5 Clinical Concerns you have to know with NSAIDs in the Elderly

Pain management can be incredibly difficult in the elderly due to the high risk of potential side effects.  NSAIDs are some of the most commonly used medications for pain.  Here’s 5 reasons why NSAIDs in the elderly may not be such a good idea. 1. NSAIDs can...
Gabapentin Dose Dependent Absorption – Treating Neuropathy

Gabapentin Dose Dependent Absorption – Treating Neuropathy

A huge challenge in clinical pharmacy is determining what information is actually relevant.  By relevant, I mean what information actually impacts patient care. I see gabapentin most frequently used for neuropathy.  The pharmacokinetics of gabapentin are a little...