Trazodone is a medication I see used in my geriatric practice on a daily basis. It is classified as a “serotonin modulator”. It has some serotonin antagonist action at lower doses and may have more serotonin agonist effects at higher dosages. In this...
CYP2D6 is an important pathway for the breakdown of certain medications. There are also some less common cases of medications that are prodrugs and activated by this enzyme. It is important to know some of these commonly used medications and how they may impact...
The Framingham risk score has been the primary method of determining a patient’s 10-year risk of cardiovascular disease. Scores such as this take into account a patient’s specific risk factors including age, gender, systolic blood pressure, total cholesterol,...
Lorazepam and clonazepam are both from the benzodiazepine family. I see them both used in clinical practice on a regular basis. While their pharmacology actions are essentially identical, there are some pharmacokinetic, dosage form, and indication differences you...
We’ve been doing some work lately to develop a chart of commonly used drugs with pharmacogenomic considerations. In anticipation of that table, I thought I’d share my top 5 medications that have pharmacogenomic considerations. If you are taking a board...
